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. 2007 Aug 8;27(32):8699–8708. doi: 10.1523/JNEUROSCI.2018-07.2007

Figure 8.

Figure 8.

C5a function. A, Paw withdrawal in response to a cold stimulus as a function of time subsequent to injection of C5a peptide into the intrathecal space of rats. Data for saline injection (filled squares; n = 7), 10 ng of C5a peptide (open circles; n = 7), and 100 ng of C5a peptide (open squares; n = 5) are shown. The area under the response-time curve (AUC) was calculated for each dose. There was a significant difference among the three doses by one-way ANOVA (F (2,16) = 8.72; p = 0.0027), with post hoc testing (Tukey's method) showing a significant difference between saline and 100 ng (p = 0.002) but not between 10 and 100 ng (p = 0.13) or between saline and 10 ng (p = 0.09). All data are mean ± SEM. B, Paw withdrawal in response to a cold stimulus (acetone evaporation) as a function of time subsequent to SNI injury in rats during continuous infusion of a C5a antagonist into the intrathecal space via an osmotic pump. Day −1 behavioral testing was before pump placement; day 0 behavioral testing was before SNI injury. There was a significant difference in the area under the response-time curve between C5a antagonist-treated (open squares; n = 12) and vehicle-treated (filled squares; n = 11) animals by Welch's two-sample t test (t = 2.17; df = 20.4; p = 0.042).