Figure 6.

Electrophysiological analysis of NFH-LacZ mice. A, Slower conduction velocities were observed in the caudal and tibial nerves of transgenic mice. Whereas the conduction velocity increases with age in normal animals, it does not increase similarly in transgenic mice. Error bars indicate SD. B, CAPs recorded from control (C) and transgenic (T) nerves. Note the decreased conduction velocity and amplitude in NFH-LacZ nerves. C, D, Latencies to the peaks were longer in transgenic mice when the auditive (C) and somesthesic evoked potentials (D) were analyzed. Error bars indicate SD. The top graphs represent typical recordings of evoked potentials in control and NFH-LacZ mice.