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. 2007 Sep 5;27(36):9801–9815. doi: 10.1523/JNEUROSCI.2661-07.2007

Figure 3.

Figure 3.

Electron microscopy analysis of VAPB-P56S aggregates in HeLa cells. A1–C2, Transmission electron photomicrographs of anti-HA immunogold labeled ultrathin sections of HeLa cells transfected with HA-VAPB-P56S. Immunogold labeling is specifically associated with clusters of electron dense tubular profiles (A). Occasionally, labeled profiles are continuous with unlabeled profiles reminiscent of ER tubules (B) or with mitochondrial outer membranes (C). Arrows indicate unlabeled ER-tubules; asterisks indicate normal appearing cytoplasm in VAPB-P56S aggregates. m, Mitochondria; nu, nucleus. Scale bars: A1, B1, C1, 200 nm; A2, B2, C2, 100 nm.