Figure 8.
Role of INa(P) in the intrinsic membrane properties of CINs in spinal cord slice preparations. A, Tonic responses to a series of current injections of a dCIN that is partially isolated from synaptic inputs by application of 50 μm AP-5, 15 μm CNQX, 10 μm strychnine, and 10 μm picrotoxin in a P2 slice. B, Riluzole abolishes the tonic responses of the dCIN to a series of current injections. C, Tonic potentials elicited by a square pulse current injection (left) are eliminated by riluzole (middle), but brief transient current pulses can still evoke spikes during the current step in the presence of riluzole.