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Reflex scores after intrathecal NGX424
| NGX424 dose (μg) | 0.1 | 0.3 | 1.0 | 3.0 | 10.0 | 30.0 |
| Reflex score | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.33 ± 0.21 | 1.67 ± 0.17 | 2.67 ± 0.22 |
Supraspinal effects of intrathecal NGX424 were monitored by checking corneal and whisker reflexes. Doses of 1.0 μ g or less appeared to have no effect on alertness, whereas higher doses seemed to have mild to severe sedative effects that are positively correlated with dose.
