Figure 3.

Concentration-dependent neurotoxicity by NMDA in mixed cortical cultures from wild-type mice (a-wt/n-wt), in cultures containing astrocytes from mGlu3 knock-out mice (a-mGlu3^−/−/n-wt), and in cultures containing neurons from mGlu2^−/− knock-out mice (a-wt/n-mGlu2^−/−). Values are means ± SEM of six to nine determinations from two to three independent experiments. *p < 0.05 (1-way ANOVA and Fisher's PLSD) versus the corresponding NMDA values obtained in a-wt/n-wt cultures.