Figure 3.

The ADAM10 pharmacological inhibitor has a dose-dependent effect on RGC axon guidance. A, Graph showing the percentages of embryos at different doses of GI254023X that have a normal RGC axon projection to the optic tectum. B, Graph showing the percentages of embryos at different doses of GI254023X that exhibit either defects in target recognition, guidance at the mid-diencephalic turn (Miss turn), or axon extension (Short). Note that some embryos show more than one defect and that the number of embryos showing target recognition defects decreases at 5 μm GI254023X because axons fail to make the turn in the mid-diencephalon and never reach their target. The numbers in parentheses are the numbers of embryos.