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. 2007 Aug 1;27(31):8309–8313. doi: 10.1523/JNEUROSCI.1781-07.2007

Figure 4.

Figure 4.

IL-4 increases neuronal CD200 expression. A, IL-4 increases CD200 protein expression in cultured neurons by Western blot (***p < 0.001). B, Fluorescent images of CD200 expression in cultured neurons in the absence (i) and presence (ii) of IL-4. C, Intracerebroventricular injection of IL-4 increases CD200 protein expression in hippocampus (*p < 0.05; n = 3). D, Fluorescent images of increased CD200 expression in hippocampus of IL-4-treated rats (ii) versus control (i). E, CD200 expression is significantly decreased in hippocampal tissue prepared from IL-4−/− mice (*p < 0.05; n = 4). F, CD200 expression is significantly decreased in cultured neurons prepared from IL-4−/− mice (ii) compared with neurons prepared from wild-type mice (i). G, MHCII mRNA expression is increased in cultured glial cells prepared from IL-4−/− mice (*p < 0.05; n = 5). H, IL-1β concentration is increased in cultured glial cells prepared from IL-4−/− mice (**p < 0.01; n = 10). Scale bars, 20 μm. Error bars indicate ±SEM. WT, Wild type.