Figure 8.

Gating models for presynaptic P/Q-, N-, and R-type channels. A, B, Modeling of voltage dependence of steady-state activation (A, open circles), activation time constant (B, open circles), delay (B, open squares), and deactivation time constant (B, filled circles) for presynaptic P/Q-type channels. C–F, Similar analysis for N-type (C, D) and R-type channels (E, F). The scheme on top indicates the structure of the kinetic model. The predictions of the models are indicated by red (activation curve, activation time constant, deactivation time constant) and green curves (delays). For model parameters, see Table 2.