Table 2.

Regions demonstrating significant effects of prenatal exposure to maternal smoking and adolescent smoking on FA

Structure	Talairach coordinates
	x	y	z	Volume (mm3)	Peak p value a
Structures with increased FA in prenatally exposed NS relative to nonexposed NS
R frontal short association fibers	40	45	1	88	0.0002
L frontal white matter	−20	32	13	160	0.002
R genu, corpus callosum	12	22	14	80	0.002
Structures with increased FA in nonexposed S relative to nonexposed NS
L inferior longitudinal fasciculus	−24	−85	4	120	0.0008
R forceps minor, corpus callosum	14	30	12	328	0.0001
R internal capsule, anterior limb	24	16	14	456	<0.0001
R frontal association fibers	16	45	14	192	<0.0001
L splenium, corpus callosum	−8	−34	15	384	0.001
L forceps minor, corpus callosum	−18	18	18	520	<0.0001
R genu, corpus callosum	12	9	24	792	0.0001
R superior longitudinal fasciculus	28	7	26	200	0.0001
R frontal short association fibers	16	32	24	80	0.0008
Structures with increased FA in exposed S relative to nonexposed NS
R internal capsule, anterior limb	15	10	4	2608	<0.0001
R genu, corpus callosum	10	27	4	2528	0.0001
L frontal white matter	−22	28	12	1544	<0.0001
R genu, corpus callosum	12	3	26	128	0.0009
R superior longitudinal fasciculus	24	3	26	96	0.001
L forceps minor, corpus callosum	−16	5	26	96	0.0007
Structures with decreased FA in exposed S relative to nonexposed NS
L external capsule	−30	−13	12	1064	0.0003

^a p value of peak group difference in FA.