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. 2007 Dec 5;27(49):13457–13467. doi: 10.1523/JNEUROSCI.3702-07.2007

Figure 2.

Figure 2.

Differential effects of theta phase on CA3-CA3 and mPP-CA3 synaptic responses during initial exploration of a novel environment. Left, Mean percent change (±SEM) in cCA3-CA3 field EPSP slopes (dV/dt) compared with baseline synaptic responses collected in the home cage (defined as 100% response magnitude for each animal). A comparison of responses evoked during the initial exploration of a novel environment show cCA3-CA3 synaptic responses are reduced during CA3 theta peaks when compared with both baseline responses collected in the home cage (home), and responses evoked on local theta troughs (*p < 0.05, Tukey's test; n = 5). Right, Mean percent change (±SEM) in mPP-CA3 synaptic responses relative to baseline responses collected in the home cage (defined as 100% of response amplitude) during the initial exploration of a novel environment. mPP-CA3 synaptic responses are reduced during local CA3 theta troughs when compared with both baseline responses collected in the home cage (home) and responses evoked on CA3 theta peaks (*p < 0.05, Tukey's test; n = 5). Calibration: 0.5 mV, 5 ms.