Figure 4.

E-cell responses to apamin match the AptSK2 distribution patterning. A, An E-cell labeled with Neurobiotin showing the presence of a basilar dendrite (arrow). B, Single-cell AHP averages generated via intracellular current injection (0.1 nA) superimposed before and after drug treatment. Neurons in the LS and CLS along with CMS intermediate cells respond to apamin (gray) with a decrease in the size of the AHP. CMS superficial cells do not show a response to apamin. C, A representative CLS cell showing an increased and persistent AHP after EBIO. D, A CMS superficial cell showing no response to EBIO. E, Elimination of the DAP after TTX application to the apical dendrites reveals that the time course of the DAP overlaps that of the apamin-sensitive AHP.