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Effects on CREB phosphorylation in vivo. A, B, A-582941 (0.01, 0.1, and 1.0 μmol/kg) increased phosphorylation of the transcription factor CREB in mouse cingulate cortex at behaviorally efficacious doses (15–20 min after injection; *p < 0.05; **p < 0.01 vs vehicle-treated control; n = 6 per treatment). Data are represented as mean ± SEM. Scale bar, 150 μm.
