Figure 1.

Timeline of the experimental design. Once animals had been trained, they were matching into groups based on their baseline performance and received intra-OFC infusions of AAVs designed to overexpress GFP, ΔFosB, or ΔJunD. Once stable postoperative performance had been established, animals were challenged with an acute cocaine dose on task. One week later, the chronic dosing regimen began. Animals received twice daily intraperitoneal injections of either saline or cocaine (15 mg/kg) in their home cages. Injections were given at least 2 h on either side of the behavioral test session. Behavioral testing continued daily during this time. Two weeks after the end of the chronic treatment, animals were again challenged with an acute dose of cocaine on task.