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. 2007 Sep 26;27(39):10445–10455. doi: 10.1523/JNEUROSCI.2883-07.2007

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Copyright © 2007 Society for Neuroscience 0270-6474/07/2710445-11$15.00/0

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Figure 3. — Arc antisense transiently inhibits early LTP expression. A, B, Nondecremental LTP of fEPSPs was induced when Arc AS was infused 90 min (A) or 15 min (B) before HFS. C, D, Infusion of Arc AS 5 min before HFS (C) or 15 min after HFS (D) resulted in transient suppression of LTP. D, Bottom, Averaged field potentials traces (4 sweeps) collected at the time points indicated in the LTP plot. E, Nondecremental LTP was observed in SC-treated controls. F, Bar graphs show changes in fEPSP and Arc protein expression in rats infused with Arc AS 5 min before HFS. Values for both were unchanged at 1 h (reversal) and significantly elevated at 3 h (recovery) after HFS (p < 0.05). fEPSP is expressed in percentage of baseline. Arc protein immunoreactivity on Western blots is expressed as percentage of contralateral control. n = 6–8 in all groups. Representative Western blots are shown at right.