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The ATP hotspot is sensitive to NK1 and μ-opioid receptor activation. A, ∫XII nerve and ∫preBötC recordings illustrating the response to local application of ATP (0.1 mm), SP (1 μm), or DAMGO (50 μm) to the ATP hotspot. Group data (n = 6) illustrating the maximum frequency increase (B) and time course of responses (C) evoked by each agonist. *Significantly different from control. Error bars indicate SEM. Rel. Freq., Relative frequency.
