Figure 9.

P2Y₁ receptor involvement in the ATP-induced frequency increase. ∫XII nerve recordings from a rhythmic medullary slice (A) and group data (B) (n = 12) comparing the responses evoked by applying ATP (0.1 mm) or the P2Y₁ receptor agonist, 2MeSADP (0.1 mm) to the preBötC. C, E, ∫XII nerve recordings illustrating that preapplication of MRS2179 (100 μm; 2 min) to the preBötC reduced the response to ATP (C) and 2MeSADP (E). Group data showing attenuation of the ATP (D) or 2MeSADP (F) response in the presence of 50 and 100 μm MRS2179 (ATP, n = 9 and 8 for 50 and 100 μm, respectively; 2MeSADP, n = 8 and 6 for 50 and 100 μm, respectively.) *Significantly different from control. Error bars indicate SEM. Rel. Freq., Relative frequency.