Table 2.

Summary statistics for overrepresented GO categories in each system and intersection between human HD caudate and models

	N 1: common GO categories overrepresented at p < 0.05 in human HD	N 2: common GO categories overrepresented at p < 0.05 in model	Intersection of N 1 and N 2	p value	# GO categories with summed ranks ≤ 20	# GO categories with summed ranks ≤ 200
Increasing genes
R6/2	166	127	14	0.036	2	12
BDNF HET	166	90	14	0.016	1	10
BDNF KO	166	196	22	0.014	0	10
3NP	186	347	34	0.006	0	13
MPTP	148	81	4	0.726	0	4
Decreasing genes
R6/2	294	230	50	<0.001	1	20
BDNF+/−	294	94	22	0.009	0	15
BDNF KO	294	206	53	<0.001	2	30
3NP	327	101	11	0.405	0	4
MPTP	271	79	20	<0.001	0	16

GO categories common to the separate human and model system pairs were identified. N ₁ is the number of these common GO categories significantly increased or decreased in human caudate. N ₂ is the number of common GO categories significantly affected in the indicated model. The number of common GO categories significantly over represented in both human HD and the indicated model is shown. p values for intersections were estimated by computer simulation. The number of GO categories in the intersections with summed ranks less than two arbitrary criteria are also shown.