Table 4.

Statistical significance of differences between strength of resemblance to human HD caudate in various sets of genes: Emx-BDNF ^KO versus all other models

System	Top 200 human changes	Top 400 human changes	Top 400 human decreases	Top 400 human increases	127 Human striatal genes	Top 400 R6/2 changes
R6/2	1.17 (1.03–1.50)	1.23 (1.07–1.62)	1.31 (1.03–1.97)	1.47 (1.29–1.87)	1.20 (1.02–1.68)	2.79 (1.81–4.53)
BDNF HET	1.10 (1.02–1.17)	1.09 (1.02–1.14)	1.12 (1.04–1.18)	0.99 (0.96–1.01)	1.11 (0.99–1.19)	1.04 (0.95–1.11)
3NP	1.19 (0.85–1.92)	1.17 (0.89–1.77)	0.94 (0.74–1.49)	1.78 (1.35–2.58)	1.56 (1.00–2.66)	1.64 (1.21–2.53)
MPTP	1.13 (1.03–1.24)	1.12 (1.03–1.22)	1.09 (1.01–1.16)	1.13 (1.03–1.23)	1.21 (1.05–1.37)	1.11 (0.99–1.21)

For each indicated set of gene, ratios of variances and 95% confidence intervals are reported. Numbers are bold if the model is less like human HD than the Emx-BDNF ^KO model and unity falls outside the 95% confidence interval. In those cases, the indicated model is significantly less like human HD than the Emx-BDNF ^KO model. Numbers are lightface if unity falls within the 95% confidence interval. In those cases, differences are considered indeterminate. It is important to note that there were no cases of a model being significantly more like human HD than the Emx-BDNF ^KO model.