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. 2007 Nov 21;27(47):12808–12816. doi: 10.1523/JNEUROSCI.0322-07.2007

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Copyright © 2007 Society for Neuroscience 0270-6474/07/2712808-09$15.00/0

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Figure 3. — MSRA overexpression extends the lifespan of the animals expressing human α-synuclein in the nervous system. A, Survival distributions of the female (left) and male (right) animals expressing α-synuclein (open circles) and α-synuclein and MSRA together (filled circles) in the nervous system. The survival distributions of the heterozygous control animals that do not express α-synuclein or MSRA are also shown (triangles and inverse triangles). Open circles, UAS-α-synuclein/elav^C155-GAL4; filled circles, UAS-α-synuclein;UAS-EGFP-MSRA/elav^C155-GAL4; triangles, UAS-α-synuclein+; inverse triangles, UAS-α-synuclein;UAS-EGFP-MSRA/+. The results from the female UAS-α-synuclein;UAS-EGFP-MSRA/+ group in this trial are not available. B, Decline in the locomotor function normalized to the survivorship. For each group, the age-dependent decline in the reactive climbing ability is plotted against the survival probability. The genotypes are as in A.