Figure 6.

Effect of NAc-specific Cdk5 KO on locomotor sensitization to repeated cocaine exposure. A, Locomotor activity in response to saline injection (S), followed by repeated 10 mg/kg cocaine injection over 5 consecutive days (1–5). Mean locomotor counts ± SEM in 10 min bins for 60 min immediately after injection for each day are shown for control (Con) versus NAc-KO groups (left). Data for the first 30 min after injection are summarized in histograms (right, *p < 0.05, **p < 0.01 compared with saline, post hoc Tukey; n = 17 per group). B, Locomotor sensitization to 15 mg/kg cocaine in control (Con) and NAc-KO mice. Time course locomotor activity and data summaries are shown as in A (***p < 0.001 compared with saline, post hoc Tukey; n = 16–19 per group).