Table 3.
Measures for K1 and Bmax′/Kd′ for the [11C]raclopride images for controls and for alcoholic subjects for the placebo (PL) and MP conditions, along with the p values for the ANOVA results for the group, drug, and interaction effects
| Drug | Controls | Alcoholics | ANOVA |
|||
|---|---|---|---|---|---|---|
| Group | Drug | Interaction | ||||
| K1 | ||||||
| Cerebellum | PL | 0.09 ± 0.02 | 0.10 ± 0.04 | NS | NS | NS |
| MP | 0.09 ± 0.03 | 0.10 ± 0.03 | ||||
| Caudate | PL | 0.09 ± 0.01 | 0.10 ± 0.02 | NS | NS | NS |
| MP | 0.09 ± 0.01 | 0.09 ± 0.02 | ||||
| Putamen | PL | 0.11 ± 0.01 | 0.11 ± 0.02 | NS | NS | NS |
| MP | 0.11 ± 0.01 | 0.11 ± 0.02 | ||||
| VS | PL | 0.09 ± 0.01 | 0.10 ± 0.02 | NS | NS | NS |
| MP | 0.09 ± 0.01 | 0.10 ± 0.03 | ||||
| Bmax′/Kd′ | ||||||
| Caudate | PL | 2.71 ± 0.35 | 2.62 ± 0.31 | NS | F = 19 | NS |
| MP | 2.32 ± 0.44 | 2.40 ± 0.32 | p < 0.0001 | |||
| Putamen | PL | 3.36 ± 0.34 | 3.32 ± 0.40 | NS | F = 54 | F = 5 |
| MP | 2.56 ± 0.45 | 2.94 ± 0.45 | p < 0.0001 | p < 0.05 | ||
| VS | PL | 2.86 ± 0.22 | 2.64 ± 0.41 | F = 8 | F = 41 | F = 13 |
| MP | 2.07 ± 0.42 | 2.42 ± 0.58 | p < 10.007 | p < 0.0001 | p < 0.001 | |
Values are means and SDs, and the measures of left and right were averaged. The ANOVA corresponds to one group (controls vs alcoholics) repeated (PL vs MP) ANOVA (df = 1,38).