Figure 11.

P4 regulation of spontaneous alternation behavior. Progesterone treatment did not significantly affect SAB performance in either 6-month-old female 3xTg-AD mice or in age-matched WT female mice. A, Compared with the OVX group of 3xTg-AD mice, P4 significantly improved the impaired SAB performance only when cotreated with E2 (F = 4.36, p = 0.03). *p < 0.05 relative to OVX. B, The number of arm entries in the task did not significantly differ across 3xTg-AD treatment groups (F = 0.37, p = 0.70). C, In WT mice, there were no significant differences in SAB performance across OVX, OVX+P4, and OVX+E2+P4 groups (F = 1.68, p = 0.22).