Figure 5.

Age-related decline in spontaneous alternation behavior. Hippocampal-dependent working memory performance in female 3xTg-AD mice was investigated by assessing SAB in a Y-maze. A, Compared with WT mice (open bars), SAB performance in female 3xTg-AD mice (filled bars) showed impairment that began at age 6 months and became statistically significant at ages 9 and 12 months (F = 16.2, p < 0.001). *p < 0.05 compared with WT. B, The number of arm entries, measured as a negative control for activity level, did not significantly vary across conditions (F = 1.14, p = 0.37).