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E2 regulation of tau hyperphosphorylation. Representative images of AT8-IR (counterstained with cresyl violet) show neurons with abnormal tau phosphorylation in female 3xTg-AD mice at age 6 months in sham OVX (A), OVX (B), and OVX+E2 (C) conditions. Scale bar, 50 μm. D, Quantification of numbers of intensely AT8-immunoreactive cells in hippocampus CA1 and subiculum show that neither OVX nor E2 treatment significantly altered tau phosphorylation (F = 2.29, p = 0.13).
