Figure 8.

E2 regulates spontaneous alternation behavior. Estrogen status significantly affected SAB performance in 6-month-old female 3xTg-AD mice but not in age-matched WT female mice. A, Compared with the sham OVX group (Sham) of 3xTg-AD mice, the OVX group exhibited significantly impaired SAB that was prevented in the OVX+E2 group (F = 14.48, p < 0.001). *p < 0.05 from relative to OVX; **p < 0.05 relative to sham. B, The number of arm entries in the task did not significantly differ across 3xTg-AD treatment groups (F = 1.87, p = 0.19). C, In contrast to results in 3xTg-AD mice, there was no significant difference in SAB performance across sham, OVX, and OVX+E2 groups in WT mice (F = 0.94, p = 0.41).