Figure 9.

P4 attenuates the effects of E2 on Aβ accumulation. Aβ-IR was visualized in female 3xTg-AD mice at age 6 months in the OVX (A, E, I), OVX+P4 (B, F, J), and OVX+E2+P4 (C, G, K) groups in hippocampus CA1 (A–C), subiculum (Sub.; E–G), and frontal cortex (F.Ctx.; I–K), as shown in representative images. Scale bar, 100 μm. Data demonstrate that mean ± SEM Aβ load did not differ significantly across treatment groups in hippocampus CA1 (F = 0.85, p = 0.45) (D), subiculum (F = 2.10, p = 0.15) (H), and frontal cortex (F = 0.58, p = 0.57) (L).