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MAP1B siRNA blocks DHPG-induced AMPAR endocytosis. A, Surface GluR2 immunostaining in neurons transfected with scrambled or MAP1B siRNAs (si). After labeling of GluR2 receptors in live neurons, cells were treated with NMDA or DHPG. Scale bar, 10 μm. B, Graph depicts effects of MAP1B siRNA on surface GluR2 as depicted in A. *p ≤ 0.05. C, MAP1B siRNA does not have effects on number of primary dendrites (# Primary Dend.) and total dendritic length (Dend. Length).
