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. 2007 Nov 28;27(48):13173–13180. doi: 10.1523/JNEUROSCI.4057-07.2007

Figure 5.

Figure 5.

a, Injection of rhHsp70 resulted in an increased percentage of innervated NMJs in the MG at P90. Mice were injected with rhHsp70 beginning at P50 and killed at P90. Transgenic mSOD1 mice had a higher percentage of innervated NMJs at this age (+ denotes rhHsp70 treated animals). Both mSOD1 groups had a lower percent innervation compared with both wild type groups. There was no difference between the wild type groups. b, Photomicrographs of NMJs in treated and untreated animals. The two NMJs remain innervated in the treated animal, whereas in the untreated animal many NMJs showed absence of or partial innervation. nAChR clusters with corresponding VAChT and neurofilament H+L are labeled. Photographs of NMJs were taken at 20×. Scale bars: 20 μm.