Figure 2.
A–C, An on-cell and off-cell recorded simultaneously in a normal, unoperated control animal illustrate characteristic burst and pause associated with reflex evoked by noxious heat (A), 100 g von Frey fiber applied to the left hindpaw (B), and 100 g von Frey fiber applied to the right hindpaw (C). EMG trace was rectified and smoothed (0.05 s) to show the magnitude and timing of the withdrawal. Individual spikes are shown for each cell. Heat stimulus (ramped from a hold temperature of 35°C to a maximum of 53°C at 1.5°C/s) was delivered using contact Peltier device. The time of von Frey fiber application is indicated by a bracket below the trace.