Figure 2.
Effect of the TRPV1 blocker BCTC on acid-evoked currents. A, BCTC (100 nm) blocks most of the sustained phase of inward current evoked by a large acidification to pH 5.0 but has little effect on the transient phase. B, The sustained inward current (left, S of S; compare Fig. 1A) and the sustained phase of the rapidly inactivating current (right, S of T/S; compare Fig. 1C) evoked by mild acidification (to pH 6.3) are partially inhibited in some cells by BCTC but unaffected in the majority.