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. 2007 Dec 26;27(52):14515–14524. doi: 10.1523/JNEUROSCI.4338-07.2007

Figure 3.

Figure 3.

Swl/+ mice exhibit lumbar proprioceptive DRG neuron and muscle spindle degeneration during development. A, Immunofluorescence stainings of developing (Egr3+) and mature (S46+) muscle spindles show that the gross morphology of muscle spindle during different stages is comparable between Swl/+ mice and WT littermate mice. Scale bar, 50 μm. B, Quantitative analysis of muscle spindle indicates that the spindle count in the Swl/+ hindlimbs is comparable with those in WT hindlimbs at E15.5 (p > 0.05, Student's t test). However, at P0.5 and P91, the number of muscle spindles is reduced by 87 and 88%, respectively, in Swl/+ mice compared with those in WT mice. *p < 0.01 (Student's t test). C, Quantitative analysis of L4 PV+ DRG neurons reveals no significant change in the number of the lumbar proprioceptive DRG neurons in Swl/+ mice at E15.5 (p > 0.05, Student's t test) but a 69% reduction in the number of Swl/+ lumbar proprioceptive DRG neurons at both P0.5 and P91 in Swl/+ mice compared with those of WT mice. *p < 0.05 (Student's t test).