Figure 6.

Proprioceptive sensory deficit is a common feature in Loa and Swl Dync1h1 mutations. A, Hindlimb grip strength is reduced by 52% in 13-week-old male Loa/+ mice, whereas no difference is detected in their forelimbs. *p < 0.01 (Student's t test). B, Quantitative analysis of muscle spindles demonstrates that Loa/+ mice have 86% fewer muscle spindles than WT mice. *p < 0.01 (Student's t test). C, Quantitative analysis of DRG neurons indicates that the number of DRG neurons is significantly reduced in L4 segment but not in C4 segment of Loa/+ mice. *p < 0.01 (Student's t test). D, In contrast to the ventral root (VR), the dorsal root (DR) and the sciatic nerve (SN) are markedly thinner in Swl/+ and Loa/+ mice compared with the WT littermate mice. Scale bar, 100 μm. E, The H reflex is absent in Loa/+ mice (n = 4) but present in three of four WT littermates.