Figure 7.
Glutamate transmission is required for the D1 receptor-induced increase in surface and synaptic GluR1 expression by DA neurons in VTA-PFC cocultures. VTA-PFC cocultures were treated with media (control group), SKF 81297 (1 μm, 10 min), the NMDA receptor antagonist APV and SKF 81297 (APV+SKF), the non-NMDA receptor antagonist CNQX and SKF 81297 (CNQX+SKF), or APV+CNQX+SKF. In the latter three groups, cocultures were incubated with antagonist(s) for 5 min and then SKF 81297 was added for 10 min. APV or CNQX completely blocked the effect of SKF 81297 (n = 19–24; Dunn's test, *p < 0.05).