Figure 4.
Progesterone mediates the changes in GABAARs related to the ovarian cycle. A, Representative immunoblots of total membrane hippocampal protein from untreated male mice or male mice treated with 5 mg/kg progesterone twice daily for 2 d alone or in combination with either finasteride or RU486. B, The histogram of average optical density of Western blots demonstrates that progesterone administration increases GABAAR δ subunit expression, which can be blocked with finasteride treatment but not with RU486. The asterisk denotes significance (p < 0.05). Error bars indicate SEM. prog, Progesterone; fina, finasteride.