Table 1.

Relative levels of the GluR1 receptor subtype in subregions of the ventral tegmental area and nucleus accumbens of rats subjected to ICES treatment of the lateral hypothalamus or the prefrontal cortex

	Cocaine-stimulated	Cocaine sham-stimulated	Saline-stimulated	Saline sham-stimulated
GluR1 in LH-treated rats
aNAc core	61 ± 22	17 ± 4b	81 ± 40	100 ± 24
aNAc shell	56 ± 21	39 ± 14b	107 ± 48	100 ± 20
pNAc core	50 ± 13	16 ± 3	52 ± 24	100 ± 42
pNAc shell	37 ± 10	23 ± 4b	41 ± 20	100 ± 37
aVTA	54 ± 38a	763 ± 213b	119 ± 43	100 ± 23
pVTA	140 ± 25	158 ± 38b	88 ± 15	100 ± 20
GluR1 in PFC-treated rats
aNAc core	123 ± 40a	36 ± 14b	70 ± 15	100 ± 36
aNAc shell	267 ± 107a	16 ± 4b	35 ± 10	100 ± 38
pNAc core	36 ± 16	16 ± 3b	18 ± 5c	100 ± 25
pNAc shell	29 ± 13	19 ± 5b	18 ± 3c	100 ± 27
aVTA	394 ± 90	395 ± 83b	77 ± 11	100 ± 19
pVTA	127 ± 23	140 ± 21	129 ± 13	100 ± 20

Rats were perfused immediately after the saline challenge, and slices were immunolabeled for GluR1. Data are presented as percentage (means ± SEM) of the average fluorescence intensity measured in the saline-pretreated sham-stimulation groups that were considered as baseline levels for each subregion. Significant differences are reported for p < 0.05.

^aSignificantly different from cocaine-pretreated sham-stimulated;

^bSignificantly different from saline-pretreated sham-stimulated;

^cSignificantly different from saline-pretreated sham-stimulated.