Figure 4.

RTN neurons from TASK channel knock-out mice retain pH sensitivity and express a pH-sensitive K⁺ current like their wild-type counterparts. A, Effects on firing rate of changing bath pH in representative RTN neurons from control (left) and TASK^−/− (right) mice. B, Averaged firing rate at the indicated extracellular pH of RTN neurons from control (n = 8), TASK-1^−/− (n = 8), TASK-3^−/− (n = 9), and TASK^−/− (n = 5) mice; there was no difference in pH sensitivity of RTN neurons from control and TASK knock-out mice. C, Averaged I–V relationships of pH-sensitive currents expressed by RTN neurons in control and TASK knock-out mice (n = 7, 7, 9, and 5; p = 0.3, by two-way RM-ANOVA).