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Effects of genetic deletion of TLR4 or IL-6 on IL-6 secretion by primary cultured skin fibroblasts. Cells were obtained from 6-week-old littermates with individual genotypes. Each bar represents the mean ± SEM of three determinations, each performed in duplicate. *p < 0.01, significantly different from the values of NPC1−/−/TLR4+/+ cells (left) or NPC1−/−/IL-6+/+ cells (right).
