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. 2007 Feb 21;27(8):1902–1912. doi: 10.1523/JNEUROSCI.5346-06.2007

Figure 5.

Figure 5.

Gαq/11 signaling and OT-evoked bursts. A–D, Effects of agents that simulate or block potential Gαq/11 signaling on burst generation. A, Blocking phospholipase C with 5 μm U73122 from 10 min before OT did not block OT-evoked bursts. B, Using PMA (1 μm for 10 min) to activate protein kinase C neither triggered nor facilitated OT-evoked bursts. C, Applying thapsigargin (Thaps.; 200 nm for 30 min) to deplete OT- and IP3-sensitive internal Ca2+ stores did not block OT-evoked bursts. D, OT-evoked bursts were intact after blocking activation of RhoA/Rho kinase with 10 μm Y27632.