Skip to main content
. 2007 Feb 21;27(8):1812–1823. doi: 10.1523/JNEUROSCI.4441-06.2007

Figure 6.

Figure 6.

PRL treatments mimic the regenerative effects of pregnancy on myelin damage in virgin females. A, Fluorescence micrographs of newly generated oligodendrocytes (BrdU+GSTπ+ cells) in the lysolecithin lesioned dorsal funiculus of VEH- versus PRL-treated females after BrdU tracing revealed an increase in the number of newly generated oligodendrocytes in the lesion of PRL-treated females (VEH, 480 ± 120, n =8; PRL, 836 ± 104, n =9; p < 0.05; unpaired t test). B, Luxol fast blue staining of myelin in the dorsal funiculus of PRL- and VEH-treated females and quantification of lesion size 14 d after lysolecithin lesions revealed a significant reduction in the size of the lesion of PRL-treated females relative to VEH (lesion size index: VEH, 9 ± 2, n =6; PRL, 5 ± 1, n =6; p < 0.05; unpaired t test). Values are means ± SEM. Scale bar, 100 μm.