Figure 4.

Inflammatory foci in wild-type and PLP/SOCS1 mice. Inflammatory foci (focus is defined as >20 cells/vessel)/mm² were measured in the H&E-stained spinal cords of PLP/SOCS1 mice. No significant inflammation was found at day 8 PI in any of the samples. Two significant differences were found in the later time points: PLP/SOCS1 mice had a higher number of inflammatory foci at days 10 and 12 PI compared with the wild-type mice (*p < 0.05) but fewer inflammatory foci at disease onset compared the wild-type mice, days 10 and 15 PI, respectively (**p < 0.05).