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. 2007 Feb 21;27(8):1981–1991. doi: 10.1523/JNEUROSCI.4321-06.2007

Figure 2.

Figure 2.

Immunoblot analysis of the effects of lithium on GSK3β, APP maturation, and tau phosphorylation in hAPP tg mice. A, Representative Western blots demonstrating the patterns of immunoreactivity of total t-GSK3β, GSK3β-p, mature (mat) and immature (imm) forms of FL APP, CTFs (C99 and C89) of APP, FL APP-p, CTF APP-p, and tau-p in homogenates from the frontal cortex of 6-month-old nontg or hAPP tg mice treated with either saline or lithium. B, Image analysis of the levels of GSK3β-p, the ratio of mature/immature FL APP, and levels of APP CTFs (mean of C99 and C89) in the frontal cortex of nontg and hAPP tg mice treated with saline or lithium. C, Image analysis of the levels of FL APP-p, CTF APP-p (mean of C99 and C89), and tau-p in the frontal cortex of nontg and hAPP tg mice treated with saline or lithium. *p < 0.05 compared with saline-treated hAPP tg mice by unpaired two-tailed Student's t test; n = 6 mice per group.