Figure 3.
Effects of lithium on GSK3β activity and APP metabolism in hAPP tg mice. A, Levels of GSK3β activity, expressed as counts per minute (CPM) per microgram of protein, in homogenates from the frontal cortex of nontg and hAPP tg mice treated with saline or lithium. B, Aβ1–42 levels in homogenates from the frontal cortex of nontg and hAPP tg mice treated with saline or lithium. C, Immunoreactivity levels of the Aβ-cleaving enzyme neprilysin in homogenates from the frontal cortex of nontg and hAPP tg mice treated with saline or lithium. D, Levels of BACE1 immunoreactivity in homogenates from the frontal cortex of nontg and hAPP tg mice treated with saline or lithium. *p < 0.05 compared with saline-treated hAPP tg mice by one-way ANOVA with post hoc Tukey–Kramer test; n = 6 mice per group.