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. 2007 Feb 7;27(6):1467–1473. doi: 10.1523/JNEUROSCI.4632-06.2007

Figure 1.

Figure 1.

Effect of early life stress (IMS) on behavioral responses to the forced swim test. Total time spent passively floating and number of passive episodes recorded during the second FST exposure of adult nontreated SFR and IMS mice (labeled C), SFR and IMS mice treated with fluoxetine between P60 and P88 [labeled F(60)] or between P32 and P61 [labeled F(32)], or exposed to postweaning environmental enrichment (E). Data represent means ± SEM of determinations made from 10 to 16 animals per group. Each group was composed of an equal number of male and female mice. Within each group, no significant differences were found in measurements obtained from male and female mice. A one-way ANOVA revealed significant differences (F(7,73) = 3.719; p = 0.0017 for passive floating time, and F(7,73) = 5.28; p < 0.0001 for the number of passive episodes) that were resolved post hoc (Tukey–Kramer multiple comparisons) as indicated. *p < 0.05 compared with SFR controls, and #p < 0.03 compared with IMS controls.