Table 1.

NMDA-induced responses in cultured MSNs from YAC HD mouse models, compared with WT FVB/N^a

Genotype	Peak NMDAR current	Peak cytosolic Ca2+	Loss of ΔΨm	Caspase 9 and 3 activation	Induction of apoptosis
YAC46	≅	↑	↑	↑	↑
YAC72	↑	↑	↑	↑	↑↑
YAC128	≅	≅	↑	N.R.	↑↑

N.R., Not reported.

^aAggregate observations as reported by Zeron et al. (2002, 2004), Shehadeh et al. (2006), and Fan et al. (2007). FVB/N indicates mouse strain background for WT and YAC transgenic mice.