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. 2007 Dec 12;27(50):13706–13718. doi: 10.1523/JNEUROSCI.3503-07.2007

Figure 7.

Figure 7.

GluR1-C-tail peptide can rescue spine enlargement in the presence of an exocytosis blocker. A, Neurons expressing eGFP-Syntaxin13ΔTM and tDimer (n = 135 spines, 3 cells). A1, Mean spine volume (integrated red fluorescence) and spine Syn13ΔTM (integrated green fluorescence) relative to chemLTP induction. Values normalized to −10 min time point (*p < 0.05). A2, Sample images obtained at indicated times relative to chemLTP induction (red channel only). Images are displayed as in Figure 2. A3, Paired whole-cell recordings of AMPAR- and NMDAR-mediated currents from uninfected cells and neighboring infected cells expressing GFP-Syn13ΔTM (n = 10). Recordings are performed as in Figure 2. B, Same as A for neurons expressing eGFP-Syntaxin13ΔTM, untagged-GluR1-C-tail peptide, and tDimer (n = 162 spines; 3 cells). B3, Coexpression of GFP-Syn13ΔTM and tDimer-GluR1-Ctail peptide, blocks LTP (paired pathway, n = 8; control pathway, n = 8). LTP induction as in Figure 2. C, Cumulative distribution of fold spine volume change during chemLTP from cells expressing GFP-Syn13ΔTM with or without untagged GluR1-C-tail. Fold volume change is defined as in Figure 2. Error bars represent SEM. Scale bar, 1 μm.