Figure 7.

Inhibition of PKCε translocation, but not PKCα activation, blocks activin A-induced TRPV1 sensitization. PKCε TIP (200 μm) added into recording pipette inhibited TRPV1 sensitization by activin, whereas PKCε NCP had no effect. Preincubation and coincubation of neurons with the PKCα/β inhibitor Gö6976 (10 nm) neither blocked activin action nor mimicked it in the absence of activin. Symbols represent mean ± SEM of the second-to-first capsaicin response ratio. **p < 0.01 relative to control; *p < 0.05 relative to activin. Numbers of observations for each condition are indicated next to each symbol.