Figure 1.

Scatterplot of thalamic canonical scores for the four subject groups. Canonical analysis was used to establish the linear combination of PC scores that maximized the difference between the SCZ and CON subjects. The resulting weighting coefficients were then used to score all subjects. Differences between groups were assessed using a mixed model with group and gender as fixed effects. Horizontal line indicates the predicted marginal mean (“least square mean”) controlling for gender [least square means (SEs) of −1.03 (0.22), −0.13 (0.18), 0.30 (0.18), and 0.45 (0.14) for SCZ, SCZ-SIB, CON-SIB, and CON, respectively].