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. 2007 Dec 12;27(50):13843–13853. doi: 10.1523/JNEUROSCI.4486-07.2007

Figure 4.

Figure 4.

Thr286 autophosphorylation of αCaMKII and Ser831 phosphorylation of GluR1 are downregulated in the PSD fraction (PSD) of cNR2B mice. A, B, Representative immunoblots (top) and the quantification (bottom) of Thr286 phosphorylation of αCaMKII in PSD (A; **p < 0.01; n = 6) and forebrain homogenates S1 fraction (B). β-Actin is used as a protein loading control. αCaMKII phosphorylation is measured by the ratio of Thr286-P-CaMKII/actin. C, D, Representative Immunoblots (top) and the quantification (bottom) of Ser831 phosphorylation of GluR1 in PSD (C; *p < 0.05; n = 8) and S1 fraction (D). GluR1 phosphorylation is measured by the ratio of Ser831-P-GluR1/GluR1. The ratio from wt/veh group is used as standard control (100) and ratios from other groups are normalized to it before statistical analysis. Quantifications are based on the average of 6–8 independent experiments. Statistical analysis was done using one sample t test (mean = 100).