Figure 7.

Tamoxifen induction reveals spatial learning deficits in the cNR2B mice. A, Time to find the hidden platform plotted versus training day. B, Percentage time spent in each quadrant during a probe trial on day 5. Grouped bars from left to right indicate four different groups. Time spent in target quadrant (TQ), adjacent left quadrant (AL), opposite quadrant (OP), and adjacent right quadrant (AR) are labeled as indicated. C, Platform quadrant crossing times during the day 5 probe test. D, Average proximity to the exact position where the platform is during training, compared with proximity to the opposite position in the pool. The data are analyzed from eight to 14 animals per group. *p < 0.05 (one-way ANOVA followed by Fisher's PLSD) reveals learning deficits in the tg/tam mice, but not in any of the other groups.